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Serum Plasminogen Activator Inhibitor‐1 and Tumor Necrosis Factor‐α Levels in Obesity and Periodontal Disease
Author(s) -
Akman Pelin Taşdelen,
Fentoğlu Özlem,
Yılmaz Gülin,
Arpak Nejat
Publication year - 2012
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2011.110548
Subject(s) - medicine , body mass index , plasminogen activator , triglyceride , obesity , plasminogen activator inhibitor 1 , gastroenterology , waist , endocrinology , bleeding on probing , tumor necrosis factor alpha , cholesterol , periodontitis
Background: Several studies have shown a possible association between periodontal disease and obesity. The aim of this study is to evaluate serum plasminogen activator inhibitor 1 (PAI‐1), tumor necrosis factor‐alpha (TNF‐α), and high‐sensitivity C‐reactive protein (hsCRP) levels in the association between obesity and periodontal disease. Methods: Two hundred individuals participated in this study. Body mass index (BMI), waist‐to‐hip ratio, plasma triglyceride (TRG), total cholesterol, low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol (HDL‐C), fasting blood glucose (FBG), hsCRP, TNF‐α, PAI‐1, and periodontal parameters (including plaque index [PI], probing depth [PD], clinical attachment level [CAL], and percentage of sites with bleeding on probing) were evaluated. Results: The groups with BMI ≥ 25 had higher median values for FBG, TRG, hsCRP, PAI‐1, PI, and CAL than did the groups with a BMI < 25 ( P <0.01). Serum TRG levels were positively correlated with PI, PD, and CAL. There were negative associations between clinical periodontal parameters and HDL‐C. There were statistically significant correlations between PAI‐1 and clinical periodontal parameters (PI, PD, and CAL). Conclusion: Serum PAI‐1 levels may play an important role in the association between periodontal disease and obesity.