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A Comparative Study of Root Defect Coverage Using an Acellular Dermal Matrix With and Without a Recombinant Human Platelet‐Derived Growth Factor
Author(s) -
Carney Christopher M.,
Rossmann Jeffrey A.,
Kerns David G.,
Cipher Daisha J.,
Rees Terry D.,
Solomon Eric S.,
RiveraHidalgo Francisco,
Beach M. Miles
Publication year - 2012
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2011.110144
Subject(s) - medicine , saline , surgery , dentistry
Background: The objective of this case series is to compare root defect coverage results and healing responses of bilateral recession defects treated with acellular dermal matrix (ADM) with and without recombinant human platelet‐derived growth factor (rhPDGF). Methods: Seventeen patients with 40 bilateral gingival recession defects were compared. Each defect was ≥2 mm and treated with ADM and a coronally advanced flap. Using split‐mouth design, the control‐side ADM was hydrated in sterile saline, whereas the test‐side ADM was hydrated in rhPDGF. The patients were evaluated at 1 week, 1 month, 3 months, and 6 months. Standardized measurements were taken preoperatively at 3 and 6 months. Healing was clinically assessed at 1 week and 1 month post‐surgically. Results: Both test and control groups showed significant gain in root defect coverage over the 6‐month period for all individuals, with the test group showing a 69.0% gain and the control group showing a 76.7% gain. Patients divided into Miller Class I and Class III defects were also found to have a significant gain in root defect coverage over 6 months. The test group showed 84.1% gain, and the control group showed 84.7% gain for Miller Class I defects. For Miller Class III defects, the test group showed 51.5% gain, and the control group showed a 60.8% gain. One week after surgery, 35% of the test group showed better healing, whereas 15% of the control group showed better healing. One month after surgery, 20% of the test group showed better healing, whereas 15% of the control group showed better healing. Conclusion: Based on the results of this case series, there were no statistically or clinically significant differences in root defect coverage, keratinized tissue, clinical attachment level, or clinical healing for treatment of root recession with a coronally advanced flap and ADM with and without rhPDGF.