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Inflammation and Genetic Risk Indicators for Early Periodontitis in Adults
Author(s) -
Stashenko Philip,
Van Dyke Thomas,
Tully Patrice,
Kent Ralph,
Sonis Stephen,
Tanner Anne C.R.
Publication year - 2011
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2010.100443
Subject(s) - periodontitis , medicine , disease , periodontal disease , genotype , population , clinical attachment loss , inflammation , dentistry , gastroenterology , biology , biochemistry , environmental health , gene
Background: This report is a further analysis of a study designed to determine clinical and microbial risk indicators for progressing periodontitis. Methods: One hundred ninety subjects who were periodontally healthy or had early signs of periodontitis (age range: 20 to 40 years) were monitored clinically at 6‐month intervals followed by supragingival cleaning. At each visit, gingival crevicular fluid (GCF) and blood were collected for determination of interleukin (IL)‐1β content (in GCF) and IL‐1 genotype (in blood). Interproximal sites with a >1.5‐mm increase in clinical attachment over 18 months were considered disease active. Characteristics were compared between active and inactive subjects. Results: IL‐1β levels in GCF increased with the severity of disease and correlated well with clinical signs of incipient disease. However, the IL‐1 genotype did not show any significant associations with disease or the extent of disease. Conclusion: Indicators of inflammation may be important clinical determinants of future periodontal disease progression, but the IL‐1 genotype was not a risk indictor for early (slight) periodontitis as defined in this subject population.