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Serum Levels of C‐Reactive Protein in Adolescents With Periodontitis
Author(s) -
López Rodrigo,
Baelum Vibeke,
Hedegaard Chris Juul,
Bendtzen Klaus
Publication year - 2011
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2010.100334
Subject(s) - interquartile range , c reactive protein , periodontitis , medicine , bleeding on probing , gastroenterology , clinical attachment loss , confounding , population , aggressive periodontitis , dentistry , inflammation , environmental health
Background: The results of several cross‐sectional studies suggested a relationship between periodontitis and higher serum levels of C‐reactive protein (CRP). Most of these studies were restricted to adult study groups with severe periodontal inflammation, and the potential effects of confounding factors were frequently overlooked. Methods: A case‐referent study comprised of 87 adolescent cases who presented with clinical attachment loss ≥3 mm recorded in ≥2 of 16 teeth and 73 controls who did not fulfill these criteria was nested in a fully enumerated adolescent population. Venous blood samples were obtained, and CRP levels were quantified, using a high‐sensitive bead‐based flow cytometric assay. The Mann‐Whitney U test was used to assess overall differences between groups. Results: The median serum CRP values for cases and controls were 64 ng/ml (interquartile range: 27 to 234 ng/ml) and 55 ng/ml (31 to 183 ng/ml), respectively ( P = 0.8). Conclusions: Serum levels of CRP were not significantly higher among subjects with periodontitis than among controls. However, a statistically significant positive association between percentages of sites with bleeding on probing and log‐transformed CRP values was observed.