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Association Between Periodontal Disease and Prostate‐Specific Antigen Levels in Chronic Prostatitis Patients
Author(s) -
Joshi Nishant,
Bissada Nabil F.,
Bodner Donald,
MacLennan Gregory T.,
Narendran Sena,
Jurevic Rick,
Skillicorn Robert
Publication year - 2010
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2010.090646
Subject(s) - prostatitis , medicine , periodontal disease , prostate specific antigen , disease , association (psychology) , prostate , antigen , immunology , psychology , cancer , psychotherapist
Background: Prostate‐specific antigen (PSA) is an inflammatory marker produced by the epithelial cells of the prostate acini. In the presence of inflammation or malignancy of the prostate, PSA levels are ≥4 ng/ml. This preliminary study was conducted to evaluate any association between periodontitis and PSA levels in chronic prostatitis patients. Methods: Thirty‐five subjects who underwent prostate biopsy because of abnormal findings on digital rectal examination or elevated PSA (≥4 ng/ml) participated in the study. Plaque and gingival indices, bleeding on probing, probing depth, and clinical attachment level (CAL) were determined. Two‐sided independent sample t tests assessed any significant differences in the PSA levels between and among the groups of prostatitis and periodontitis. Results: Mean PSA levels were significantly higher ( P = 0.04) in subjects with moderate/severe prostate inflammation than those with none/mild (8.8 ± 5.8 versus 5.7 ± 3.1 ng/ml). Subjects with CAL ≥2.7 mm had higher but not statistically significant PSA levels than those with CAL <2.7 mm (7.7 ± 5.2 versus 5.7 ± 3.2 ng/ml), respectively. Individuals having both moderate/severe prostatitis and CAL ≥2.7 mm (10.8 ± 7 ng/ml) had significantly higher mean PSA levels ( P = 0.05) than those with neither condition (5.6 ± 3.7 ng/ml) nor only CAL ≥2.7 mm (5.7 ± 2.4 ng/ml) or moderate/severe prostatitis (6 ± 1.9 ng/ml). Conclusion: Subjects having comorbidity of CAL ≥2.7 mm and moderate/severe prostatitis have higher PSA levels than those with either condition alone.