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Clinical Periodontal and Microbiologic Parameters in Patients With Acute Myocardial Infarction
Author(s) -
Stein Jamal M.,
Kuch Bernhard,
Conrads Georg,
Fickl Stefan,
Chrobot Jaroslaw,
Schulz Susanne,
Ocklenburg Christina,
Smeets Ralf
Publication year - 2009
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2009.090170
Subject(s) - aggregatibacter actinomycetemcomitans , medicine , tannerella forsythia , odds ratio , bleeding on probing , myocardial infarction , periodontitis , gastroenterology , actinobacillus , body mass index , clinical attachment loss , confidence interval , prevotella intermedia , chronic periodontitis , porphyromonas gingivalis , gingival and periodontal pocket , cardiology , pathology , honeysuckle , alternative medicine , traditional chinese medicine
Background: The aim of this study was to evaluate the impact of clinical periodontal parameters and the presence of periodontal pathogens in patients with acute myocardial infarction (AMI). Methods: A total of 104 subjects (54 patients with AMI and 50 healthy controls) were included. Subgingival plaque samples were analyzed for periodontal pathogens Aggregatibacter actinomycetemcomitans ( Aa ; previously Actinobacillus actinomycetemcomitans ), Porphyromonas gingivalis ( Pg ), Tannerella forsythia ( Tf ; previously T. forsythensis ), and Prevotella intermedi a ( Pi ) using dot‐blot hybridization. Results: Patients with AMI had a significantly higher frequency of probing depths (PDs) ≥4 mm than controls (39.2% versus 14.9%; P <0.0001). Among different cutoff levels, the frequency of >50% sites with PDs ≥4 mm showed the highest discrepancy between both groups (33% versus 0%; P <0.001). All periodontal pathogens were overrepresented in patients with AMI and positively correlated with increased periodontal PD and clinical attachment level (CAL). After adjustment for age, gender, smoking, body mass index, hypertension, plaque index, statin intake, and ratio of cholesterol to high‐density lipoprotein, Pg remained a significant predictor for AMI (odds ratio [OR]: 13.6; 95% confidence interval [CI]: 3.1 to 59.8; P = 0.0005). Furthermore, the simultaneous presence of Aa + Pg ( P = 0.0005) and Aa + Pg + Tf ( P = 0.0018) were found with significantly higher frequency in patients with AMI than controls. Conclusions: The results of our study confirm an association between periodontitis and AMI in which periodontal destruction was correlated with the presence of periodontal pathogens. In particular, Pg might be considered a potential risk indicator for AMI.