Premium
Results From the Periodontitis and Vascular Events (PAVE) Study: A Pilot Multicentered, Randomized, Controlled Trial to Study Effects of Periodontal Therapy in a Secondary Prevention Model of Cardiovascular Disease
Author(s) -
Offenbacher Steven,
Beck James D.,
Moss Kevin,
Mendoza Luisito,
Paquette David W.,
Barrow David A.,
Couper David J.,
Stewart Dawn D.,
Falkner Karen L.,
Graham Susan P.,
Grossi Sara,
Gunsolley John C.,
Madden Theresa,
Maupome Gerardo,
Trevisan Maurizio,
Van Dyke Thomas E.,
Genco Robert J.
Publication year - 2009
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2009.080007
Subject(s) - medicine , scaling and root planing , randomized controlled trial , periodontitis , chronic periodontitis , odds ratio , confidence interval , clinical attachment loss , dentistry , physical therapy
Background: In the Periodontitis and Vascular Events (PAVE) pilot study, periodontal therapy was provided as an intervention in a secondary cardiac event prevention model through five coordinated cardiac–dental centers. Methods: Subjects were randomized to either community care or protocol provided scaling and root planing to evaluate effects on periodontal status and systemic levels of high‐sensitivity C‐reactive protein (hs‐CRP). Results: After 6 months, there was a significant reduction in mean probing depth and extent of 4‐ or 5‐mm pockets. However, there were no significant differences in attachment levels, bleeding upon probing, or extent of subgingival calculus comparing subjects assigned to protocol therapy (n = 151) to those assigned to community care (n = 152). Using intent‐to‐treat analyses, there was no significant effect on serum hs‐CRP levels at 6 months. However, 48% of the subjects randomized to community care received preventive or periodontal treatments. Secondary analyses demonstrated that consideration of any preventive or periodontal care (i.e., any treatment) compared to no treatment showed a significant reduction in the percentage of people with elevated hs‐CRP (values >3 mg/l) at 6 months. However, obesity nullified the periodontal treatment effects on hs‐CRP reduction. The adjusted odds ratio for hs‐CRP levels >3 mg/l at 6 months for any treatment versus no treatment among non‐obese individuals was 0.26 (95% confidence interval: 0.09 to 0.72), adjusting for smoking, marital status, and gender. Conclusion: This pilot study demonstrated the critical role of considering obesity as well as rigorous preventive and periodontal care in trials designed to reduce cardiovascular risk.