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Moxifloxacin as an Adjunctive Antibiotic in the Treatment of Severe Chronic Periodontitis
Author(s) -
Guentsch Arndt,
Jentsch Holger,
Pfister Wolfgang,
Hoffmann Thomas,
Eick Sigrun
Publication year - 2008
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2008.070493
Subject(s) - medicine , chronic periodontitis , scaling and root planing , moxifloxacin , gastroenterology , periodontitis , antibiotics , bleeding on probing , adjunctive treatment , randomized controlled trial , ofloxacin , ciprofloxacin , microbiology and biotechnology , biology
Background: The impact of moxifloxacin (MOX) was analyzed in the treatment of severe chronic periodontitis. Methods: In a randomized, prospective, clinical multicenter trial, 92 subjects with severe chronic periodontitis were treated with scaling and root planing (SRP) alone (control group; n = 21), SRP plus adjunctive doxycycline (DOX group; n = 36), or SRP plus adjunctive MOX (MOX group; n = 35). Probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) were recorded at baseline and at 3, 6, and 12 months after non‐surgical periodontal treatment. The load of periodontopathogens, the level of interleukin‐8, and the activities of granulocyte elastase and myeloperoxidase were also measured. Results: All three procedures led to significant reductions in PD, CAL, and BOP. PD reduction was significantly greater ( P <0.05) in the MOX group (2.46 ± 1.17 mm at 6 months and 2.84 ± 1.53 mm at 12 months) compared to the DOX group (1.85 ± 1.24 mm and 2.19 ± 1.13 mm at 6 and 12 months, respectively) and the controls (1.77 ± 0.57 mm and 1.86 ± 0.56 mm at 6 and 12 months, respectively). Only in the MOX group was the load of all investigated bacteria and all inflammatory parameters reduced at each appointment compared to baseline. Conclusions: The adjunctive application of antibiotics improved the treatment outcome in subjects with severe chronic periodontitis. MOX seemed to be more effective than DOX and might be an alternative drug in the treatment of periodontal diseases.