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Clinical Evaluation of Nanocrystalline Hydroxyapatite Paste in the Treatment of Human Periodontal Bony Defects – A Randomized Controlled Clinical Trial: 6‐Month Results
Author(s) -
Kasaj Adrian,
Röhrig Bernd,
Zafiropoulos GregoryGeorge,
Willershausen Brita
Publication year - 2008
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2008.070378
Subject(s) - dentistry , medicine , randomized controlled trial , clinical trial , nanocrystalline material , orthodontics , materials science , surgery , pathology , nanotechnology
Background: The aim of this study was to compare the clinical outcome of intrabony periodontal defects following treatment with a novel nanocrystalline hydroxyapatite (NHA) paste to open flap debridement. Methods: Twenty‐eight subjects, each displaying one intrabony defect with probing depth (PD) ≥6 mm and radiographic evidence of an intraosseous component ≥3 mm participated in the present study. Subjects were allocated randomly to treatment with NHA paste (test group) or open flap debridement (control group). At baseline and at 6 months after surgery, the following clinical parameters were recorded by a masked examiner: plaque index, gingival index, PD, clinical attachment level (CAL), and gingival recession. Results: A significant improvement in PD and CAL was observed at 6 months after surgery compared to baseline in both treatment groups ( P <0.001). At 6 months following therapy, the test group showed a reduction in mean PD from 7.4 ± 1.3 mm to 3.4 ± 1.2 mm and a change in mean CAL from 8.0 ± 1.3 mm to 4.4 ± 1.7 mm, whereas in the control group the mean PD decreased from 7.4 ± 0.8 mm to 4.9 ± 0.9 mm, and mean CAL decreased from 8.1 ± 1.2 mm to 6.4 ± 1.3 mm. The intergroup comparison demonstrated significantly more PD reductions ( P = 0.012) and CAL gains ( P = 0.005) in the test group compared to the control group. Conclusion: Treatment of intrabony periodontal defects with NHA paste significantly improved clinical outcomes compared to open flap debridement.