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Enhanced Bone Regeneration in Beagle Dogs With Bovine Bone Mineral Coated With a Synthetic Oligopeptide
Author(s) -
Park JunBeom,
Lee JueYeon,
Park YoonJeong,
Rhee SangHoon,
Lee SangCheol,
Kim TaeIl,
Seol YangJo,
Lee YongMoo,
Ku Young,
Rhyu InChul,
Han SooBoo,
Chung ChongPyoung
Publication year - 2007
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2007.070108
Subject(s) - beagle , oligopeptide , regeneration (biology) , bone mineral , dentistry , chemistry , biology , medicine , endocrinology , microbiology and biotechnology , biochemistry , osteoporosis , peptide
Background: Recombinant human bone morphogenic protein‐2 stimulates bone augmentation in animal models. The aim of this study was to evaluate the capacity of bovine bone mineral coated with synthetic oligopeptides to enhance guided bone regeneration in the beagle 3‐wall defect model and the clinical implications. Methods: The second and fourth mandibular premolars of four adult beagle dogs were extracted bilaterally, and the extraction sites were allowed to heal for 2 months. An L‐shaped defect was prepared at the central part of the extraction site with a round bur on a low‐speed motor. Peptide‐coated bone mineral was implanted on one side, and uncoated bone mineral was implanted on the other side. The membrane was tucked underneath the mobilized lingual flap. New bone formation at the test and control sites was determined at 4 weeks. Results: No specimen revealed any evidence of infection or foreign body reaction, and all wounds showed a good healing response. Sites augmented with peptide‐coated bone mineral and uncoated mineral exhibited excellent maintenance of the ridge contour. There was more new bone at sites with peptide‐coated bone mineral than at control sites. The new bone in sites with peptide‐coated bone mineral was deposited evenly around the graft material, and bone mineral was integrated fully into the new bone. Conclusion: Deproteinized cancellous bovine bone coated with synthetic oligopeptides enhanced new bone formation, and it seemed to be a better material for guided bone regeneration in the beagle L‐shaped defect model.