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The Influence of Cyclosporin A on Mechanical Retention of Dental Implants Previously Integrated to the Bone: A Study in Rabbits
Author(s) -
Sakakura Celso E.,
Margonar Rogerio,
Sartori Rafael,
Morais Juliana A.N.D.,
Marcantonio Elcio
Publication year - 2006
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2006.050290
Subject(s) - osseointegration , dentistry , implant , medicine , bone remodeling , saline , dental implant , group b , bone healing , surgery
Background: Immunosuppressive agents may induce severe changes on bone metabolism and may impair the osseointegration process during the implant healing. No data are available concerning the influence of cyclosporin A on dental implants previously integrated to the bone. The aim of this study was to evaluate the influence of cyclosporin A administration on the mechanical retention of bone previously integrated to dental implants. Methods: Eighteen female New Zealand rabbits were submitted to an implant surgery. Each animal received one commercial dental implant of 10 × 3.75 mm. After 12 weeks of an undisturbed healing period, six animals were randomly sacrificed and the removal torque test was performed (group A). In addition, six animals were submitted to a daily injection of cyclosporin A in a dosage of 10 mg/kg (group C), and six animals received saline solution as a control (group B). After 12 weeks of cyclosporin A administration, groups B and C were sacrificed and submitted to a removal torque test in which higher values can be interpreted as higher mechanical bone retention to the implant surface or higher osseointegration. Results: The removal torque results were 30.5 (±9.8) Ncm for group A, 50.17 (±17.5) Ncm for group B, and 26 (±7.8) Ncm for group C. The statistical analysis showed significant differences between groups A and B ( P <0.05) and groups B and C ( P <0.01). Conclusion: Cyclosporin A administration may impair the mechanical retention of dental implants previously integrated to the bone.