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Effect of a Controlled‐Release Chlorhexidine Chip on Clinical and Microbiological Parameters and Prostaglandin E 2 Levels in Gingival Crevicular Fluid
Author(s) -
Mızrak Tansel,
Güncü Güliz N.,
Çağlayan Feriha,
Balcı Tansel Ansal,
Aktar Gülseren Samancı,
İpek Fikret
Publication year - 2006
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2006.050105
Subject(s) - chlorhexidine , dentistry , prostaglandin , prostaglandin e , prostaglandin e2 , chemistry , medicine
Background: The aim of the present study was to determine the effect of a chlorhexidine chip on crevicular prostaglandin E 2 (PGE 2 ) levels and on the clinical and microbiological parameters of periodontitis when used as adjunctive therapy to scaling and root planing (SRP) in patients with chronic periodontitis. Methods: This randomized single‐blind study was carried out in parallel design. The test group received SRP plus chlorhexidine chip, whereas the control group received SRP alone. Thirty‐four subjects, aged 20 to 55 years, with chronic periodontitis were recruited. Clinical indices, microbiological samples, and gingival crevicular fluid (GCF) samples were evaluated at baseline and after 1, 3, and 6 months. Microbiological samples were evaluated under a light microscope. GCF PGE 2 levels were determined using radioimmunoassay. Results: Significant improvements could be found for all clinical variables in both groups over the study period. The mean changes in probing depth obtained by SRP plus chlorhexidine chip were greater than those obtained by the SRP alone group at 3 and 6 months. In the test group, there was also significant gain in clinical attachment level at 6 months. When data were combined from all groups, significant reductions in GCF PGE 2 levels and number of microorganisms were noted at all time points. However, in the test group, reduction was greater at 6 months for crevicular PGE 2 level and at 3 and 6 months for proportions of spirochetes. Conclusion: Based on the findings of this study, the chlorhexidine chip reduced GCF PGE 2 levels and had positive effects on clinical parameters and subgingival flora when used as adjunctive therapy to SRP in patients with chronic periodontitis.