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Age‐Related and Surgically Induced Estrogen Deficiencies May Differently Affect Bone Around Titanium Implants in Rats
Author(s) -
Duarte Poliana Mendes,
Gonçalves Patrícia Furtado,
Zaffalon Casati Márcio,
Sallum Enilson Antonio,
Nociti Francisco H.
Publication year - 2005
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2005.76.9.1496
Subject(s) - implant , medicine , cancellous bone , dentistry , cortical bone , estrogen , titanium , osseointegration , surgery , anatomy , chemistry , organic chemistry
Background: Valuable information has been obtained using the ovariectomy model; however, clinical studies have indicated that such a model may not be appropriate to parallel with the postmenopausal condition and titanium implants. Thus, this study aimed to comparatively evaluate, by histometric analysis, the influence of age‐related (ARED) and surgically induced (OVX) estrogen deficiencies on bone around titanium implants inserted in rats. Methods: Single screw‐shaped titanium implants were placed in rat tibiae and animals were then assigned to one of the following groups: SHAM (N = 15): bilateral sham ovariectomies in 90‐day‐old rats, 21 days before implant placement; OVX (N = 15): bilateral ovariectomies in 90‐day‐old rats, 21 days before implant placement; and ARED (N = 15): implant placement in reproductive aged rats (22 months old). After 60 days, the animals were sacrificed and undecalcified sections obtained. Boneto‐ implant contact (BIC) and bone area (BA) within the limits of implant threads and bone density (BD) in a 500 µm‐wide zone lateral to the implant were obtained and arranged for cortical (zone A) and cancellous (zone B) bone regions. Results: For zone A, intergroup analysis showed no signifi‐ cant differences regarding BIC and BA ( P >0.05). In contrast, ARED negatively influenced BD around the implants ( P <0.05). In zone B, OVX negatively affected BIC and BA ( P <0.05), and both ARED and OVX groups demonstrated lower BD than the SHAM group ( P <0.05). Conclusion: Within the limits of this study, it can be concluded that ARED mainly affects preexisting bone while OVX more significantly affects both newly formed and preexisting bone. J Periodontol 2005;76:1496‐1501 .