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FcγRIIIb Genotypes and Smoking in Periodontal Disease Progression Among Community‐Dwelling Older Adults in Japan
Author(s) -
Yoshihara Akihiro,
Sugita Noriko,
Yamamoto Kouji,
Kobayashi Tetsuo,
Hirotomi Toshinobu,
Ogawa Hiroshi,
Miyazaki Hideo,
Yoshie Hiromasa
Publication year - 2005
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2005.76.2.250
Subject(s) - odds ratio , genotype , confidence interval , medicine , clinical attachment loss , diabetes mellitus , periodontitis , periodontal disease , chronic periodontitis , dentistry , gastroenterology , disease , endocrinology , biology , genetics , gene
Background: FcγRIIIb genotypes and smoking are risk factors for periodontal disease. However, the interaction of FcγRIIIb‐ NA1‐NA2 polymorphism with smoking remains unclear. The purpose of this study was to determine if FcγRIIIb‐NA1‐NA2 polymorphism and smoking are associated with periodontal disease progression among elderly people. Methods: Among 70‐year‐old subjects, 164 with neither diabetes mellitus nor blood sugar ≥140 mg/dl, who had more than 20 teeth and who could participate in both the baseline and the follow‐up examinations were included in the study. The NA1 group comprised subjects with FcγRIIIb‐NA1NA1 genotype (N = 53), while the NA2 group included subjects with FcγRIIIb‐NA1NA2 or NA2NA2 genotype (N = 111). We examined the progression of periodontitis by measuring attachment loss during 3 years. Results: The frequency of subjects who showed ≥4 mm additional attachment loss at one or more sites was 55.6% for smokers and 37.2% for non‐smokers. The odds ratio (OR) was 2.13 (confidence interval [CI]: 0.92 to 4.76). We found a better association between periodontal progression and smoking in the NA2 group. The OR for smokers was 3.03 (CI:1.12 to 8.33, P = 0.028). Additionally, the mean number of sites with ≥4 mm additional attachment loss per person between smokers and non‐smokers in the NA2 group or between smokers and non‐smokers in the NA1 group was 2.90 ± 3.42 and 0.74 ± 1.53 or 0.57 ± 0.79 and 0.68 ± 1.03, respectively ( P <0.001; analysis of variance [ANOVA]). Conclusion: Our results may suggest an association between smoking and periodontal disease progression in elderly people with FcγRIIIb‐NA2 polymorphism. J Periodontol 2005;76:250‐255 .