Premium
Estrogen and/or Calcium Plus Vitamin D Increase Mandibular Bone Mass
Author(s) -
Hildebolt Charles F.,
Pilgram Thomas K.,
Dotson Mary,
ArmamentoVillareal Reina,
Hauser Jay,
Cohen Sheldon,
Civitelli Roberto
Publication year - 2004
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2004.75.6.811
Subject(s) - estrogen , calcium , vitamin d and neurology , bone mass , medicine , dentistry , endocrinology , osteoporosis
Background: We have previously reported that estrogen/ hormone replacement therapy (E/HRT) has beneficial effects on oral bone density over 3 years and that calcium and vitamin D supplementation has a lesser effect. Here we report on mandibular bone mass for 49 women (of the original cohort of 135) who continued in an additional 2‐year, open‐label extension. Methods: Postmenopausal women were randomly assigned to receive calcium and vitamin D plus E/HRT, or calcium and vitamin D only. Regression analysis of mandibular bone mass over time was performed for each woman. Results: Twenty‐two of 26 women who took calcium and vitamin D plus E/HRT for 5 years had small mandibular bone mass increases (0.35 ± 0.38%, P <0.001). Seventeen of 19 women who took only calcium and vitamin D for 3 years had increases in mandibular bone mass (0.74 ± 0.89%, P <0.002). The largest gains in mandibular bone mass occurred during the first 3 years of the study. Conclusions: The data of this study indicate that E/HRT and/or calcium and vitamin D may result in increases of mandibular bone mass in postmenopausal women. Because of the longterm risks associated with E/HRT, caution should be exercised in prescribing E/HRT for prevention of chronic menopausal conditions. J Periodontol 2004;75:811‐816 .