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Alveolar Bone Regeneration for Immediate Implant Placement Using an Injectable Bone Substitute: An Experimental Study in Dogs
Author(s) -
Boix Damien,
Gauthier Olivier,
Guicheux Jérôme,
Pilet Paul,
Weiss Pierre,
Grimandi Gaël,
Daculsi Guy
Publication year - 2004
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2004.75.5.663
Subject(s) - dentistry , beagle , dental alveolus , implant , medicine , osseointegration , bone formation , dental implant , surgery , endocrinology
Background: The aim of the present study was to assess the efficacy of a ready‐to‐use injectable bone substitute for bone regeneration around dental implants placed into fresh extraction sockets. Methods: Third and fourth mandibular premolars were extracted from three beagle dogs and the interradicular septa were surgically reduced to induce a mesial bone defect. Thereafter, titanium implants were immediately placed. On the left side of the jaw, mesial bone defects were filled with an injectable bone substitute (IBS), obtained by combining a polymer and biphasic calcium phosphate ceramic granules. The right defects were left unfilled as controls. After 3 months of healing, specimens were prepared for histological and histomorphometric evaluations. Results: No post‐surgical complications were observed during the healing period. In all experimental conditions, histological observations revealed a lamellar bone formation in contact with the implant. Histomorphometric analysis showed that IBS triggers a significant ( P <0.05) increase in terms of the number of threads in contact with bone, bone‐to‐implant contact, and peri‐implant bone density of approximately 8.6%, 11.0%, and 14.7%, respectively. In addition, no significant difference was observed when number of threads, bone‐to‐implant contact, and bone density in the filled defects were compared to the no‐defect sites. Conclusion: It is concluded that an injectable bone substitute composed of a polymeric carrier and calcium phosphate significantly increases bone regeneration around immediately placed implants. J Periodontol 2004;75:663‐671 .