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Association of Fcγ Receptor IIa Genotype With Chronic Periodontitis in Caucasians
Author(s) -
Yamamoto Kouji,
Kobayashi Tetsuo,
Grossi Sara,
Ho Alex W.,
Genco Robert J.,
Yoshie Hiromasa,
De Nardin Ernesto
Publication year - 2004
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2004.75.4.517
Subject(s) - genotype , medicine , allele , aggressive periodontitis , gastroenterology , periodontitis , biology , genetics , gene
Background: Functional polymorphisms of immunoglobulin G (IgG) Fc receptors IIIa and IIIb (FcγRIIIa and FcγRIIIb) have been shown as risk factors for periodontitis. The aim of this study is to examine whether FcγRIIa polymorphism is associated with a disease risk as well. Methods: Baseline periodontal and general health examinations were carried out on 1,221 Caucasian adults. From these, 422 subjects with moderate to severe, or little or no periodontal disease were assigned to two groups according to their mean clinical attachment loss (CAL). Subjects with mean CAL ≥2.94 mm were diagnosed with chronic periodontitis (n = 213, 62 never‐smokers and 151 smokers). Subjects with mean CAL ≤1.77 mm were considered as having little or no periodontal disease and designated as controls (n = 209, 125 never‐smokers and 84 smokers). The FcγRIIa genotype for three bi‐allelic polymorphisms (FcγRIIa‐R/ R131, R/H131, and H/H131) was determined by means of allelespecific polymerase chain reactions. Results: The distribution of FcγRIIa genotype between the patient and control groups was significantly different, with enrichment of the high ligand‐binding genotype FcγRIIa‐H/H131 in the patients (patients versus controls: 36.6% versus 25.4%; P = 0.04). Multivariate logistic regression model demonstrated that subject age and gender, smoking, and the FcγRIIa genotype were significantly associated with severity of chronic periodontitis. For smokers, a signifi‐ cant over‐representation of FcγRIIa‐H/H131 in the patient group compared to the control group (patients versus controls: 35.1% versus 19.0%; P = 0.03). Additionally, smokers with FcγRIIa‐H/H131 exhibited significantly greater mean CAL (mean ± SE: 3.44 ± 0.16 mm) than those with FcγRIIa‐R/H131 (2.91 ± 0.14 mm) and R/R131 (2.82 ± 0.16 mm) ( P = 0.04). There was no association between FcγRIIa genotype and the disease susceptibility or severity in subjects who had never smoked. Conclusions: Our results suggest that the FcγRIIa‐H/H131 genotype may be associated with chronic periodontitis risk (and disease severity) in Caucasian smokers. Further studies with families and studies of mechanisms are necessary to help establish the extent to which this is a genetic determinant of periodontal diseases. J Periodontol 2004;75:517‐522 .