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Locally Delivered Doxycycline as an Adjunctive Therapy to Scaling and Root Planing in the Treatment of Smokers: A Clinical Study
Author(s) -
Machion Luciana,
Andia Denise Carleto,
Benatti Bruno Braga,
Carvalho Marcelo Diniz,
NogueiraFilho Getúlio R.,
Casati Márcio Zafallon,
Nociti Francisco H.,
Sallum Enilson Antonio
Publication year - 2004
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2004.75.3.464
Subject(s) - scaling and root planing , medicine , doxycycline , bleeding on probing , gingival recession , dentistry , chronic periodontitis , periodontitis , periodontal disease , gingival and periodontal pocket , antibiotics , microbiology and biotechnology , biology
Background: The aim of this clinical study was to evaluate the association of locally delivered doxycycline (10%) with scaling and root planing in the periodontal treatment of smokers. Methods: Forty‐three patients with chronic periodontitis and a minimum of four pockets (≥5 mm) on anterior teeth that bled on probing were selected. Patients were randomly assigned to scaling and root planing (SRP) or scaling and root planing followed by local application of doxycycline (SRP‐D). Plaque, bleeding on probing, gingival recession, relative attachment level RAL), and probing depth (PD) were recorded at baseline, 45 days, and 3 and 6 months. Differences between baseline and each period were considered for analysis. Results: At 6 months, no difference was found between groups regarding plaque, bleeding reduction, gingival recession or PD ( P >0.05). However, RAL gain was greater for SRP‐D (1.63 ± 0.93 mm) than for SRP (1.04 ± 0.71 mm) ( P = 0.025). In addition, deep pockets (≥7 mm) showed a significant reduction (3.78 ± 1.41 versus 2.60 ± 1.28 mm, P = 0.039) and RAL gain (2.54 ± 1.27 mm versus 1.29 ± 0.95 mm, P = 0.01) when doxycycline was applied. The proportion of sites showing RAL gain of 1 to 2 mm was 36.8% versus 21.7% for SRP‐D and SRP, respectively ( P = 0.01). Conclusion: The use of locally delivered doxycycline may constitute an important adjunct for the treatment of severe periodontal disease in smokers. J Periodontol 2004;75:464‐469 .