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Microbiological Changes With the Use of Locally Delivered Doxycycline in the Periodontal Treatment of Smokers
Author(s) -
Machion Luciana,
Andia Denise Carleto,
Saito Daniel,
Klein Marlize Inês,
Gonçalves Reginaldo Bruno,
Casati Márcio Zafallon,
Nociti Francisco H.,
Sallum Enilson Antonio
Publication year - 2004
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2004.75.12.1600
Subject(s) - doxycycline , scaling and root planing , actinobacillus , dentistry , porphyromonas gingivalis , medicine , chronic periodontitis , periodontitis , significant difference , microbiology and biotechnology , biology , antibiotics
Background: The aim of this study was to evaluate the effect of the association of locally delivered doxycycline 10% and scaling and root planing in the subgingival plaque of smokers. Methods: Sixteen smokers with chronic periodontitis and a minimum of four pockets ≥5 mm) on anterior teeth that bled on probing were selected. Patients were randomly assigned to one of the following groups: scaling and root planing (SRP) or scaling and root planing followed by local application of doxycycline (SRP‐D). Subgingival plaque samples were collected from initially moderate (5 to 6 mm) and deep (≥7 mm) pockets at baseline and 3 months. Polymerase chain reaction (PCR) analysis was used to detect the frequency of Actinobacillus actinomycetemcomitans ( Aa ), Porphyromonas gingivalis ( Pg ), and Tannerella forsythensis ( Tf ). Results: No statistically significant difference was found in the reduction of Aa in either the SRP‐D or SRP group ( P >0.05). The reduction in Tf, Pg , and Tf + Pg was statistically significant for SRP‐D only ( P = 0.016, 0.027, and 0.027, respectively). The proportion of sites free of Tf at 3 months was 53% for SRP‐D and 9% for SRP ( P = 0.02). For Pg , this proportion was 82% and 40%, respectively ( P = 0.05). Conclusion: The use of locally delivered doxycycline may promote the elimination of T. forsythensis and P. gingivalis in a greater proportion of sites compared to conventional scaling and root planing in smokers. J Periodontol 2004;75:1600‐1604 .