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Effect of the Interleukin‐1 Genotype on Outcomes of Regenerative Periodontal Therapy With Bone Replacement Grafts
Author(s) -
Weiss Oren I.,
Caton Jack,
Blieden Timothy,
Fisher Susan G.,
Trafton Sarah,
Hart Thomas C.
Publication year - 2004
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2004.75.10.1335
Subject(s) - medicine , genotype , bleeding on probing , dentistry , gastroenterology , periodontal disease , biology , biochemistry , gene
Background: Previous studies have shown an association between a specific genotype for the inflammatory cytokine interleukin (IL)‐1 and the severity of periodontal disease. The purpose of this study was to evaluate the effect of the IL‐1 genotype on the outcomes of periodontal surgical regenerative treatment with bone replacement grafts. Methods: Forty‐four patients with interproximal intrabony defects were treated with bone replacement grafts. Probing depths (PD) and clinical attachment levels (CAL) were measured before treatment and at least 9 months post‐treatment. Whole‐mouth plaque index (WMPI) and bleeding index (WMBI) were recorded as well. All patients were tested for the IL‐1 genotype. Results: Thirteen (29.55%) of the patients were IL‐1 genotype positive. There was no statistically significant difference between the genotype‐positive and genotype‐negative groups regarding age, smoking status, gender, WMPI, and WMBI. There was no significant difference in PD or CAL between the genotype‐positive and genotype‐negative groups at baseline. Genotype‐positive patients had a smaller reduction in probing depth (1.86 mm versus 2.13 mm) and a greater gain of clinical attachment (1.20 mm versus 0.65 mm). These differences were not statistically significant ( P = 0.70, P = 0.40). Multivariate regression analysis showed that presurgical PD significantly influenced post‐surgical PD and CAL, and only WMPI significantly influenced CAL. Conclusion: In this study, there was no evidence that the IL‐1 genotype influences the clinical treatment outcomes of regenerative periodontal therapy with bone replacement grafts. J Periodontol 2004;75:1335‐1342 .