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Inhibitory Effects of Incadronate on the Progression of Rat Experimental Periodontitis by Porphyromonas gingivalis Infection
Author(s) -
TaniIshii Nobuyuki,
Minamida Genshi,
Saitoh Daisuke,
Chieda Keiko,
Omuro Hiromasa,
Sugaya Akira,
Hamada Nobushiro,
Takahashi Yusuke,
Kiyohara Shiro,
Kashima Isamu,
Teranaka Toshio,
Umemoto Toshio
Publication year - 2003
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2003.74.5.603
Subject(s) - porphyromonas gingivalis , periodontitis , periodontal fiber , bone resorption , resorption , placebo , medicine , osteoclast , dentistry , bisphosphonate , endocrinology , chemistry , osteoporosis , pathology , alternative medicine , receptor
Background: Incadronate (YM175, disodium cycloheptylaminomethylenediphosphonate monohydrate), a bisphosphonate, has been suggested to prevent the bone resorption associated with periodontitis by inhibiting osteoclast activity. The purpose of this study was to investigate the effect of incadronate in preventing periodontal destruction in rats with Porphyromonas gingivalis ‐induced periodontitis. Methods: Periodontitis was induced in 35 Wister rats by inoculating P. gingivalis into the oral cavity and feeding the rats a soft diet for 4 weeks. Incadronate or placebo was administered to the oral cavity of the rats 2 days per week for 2, 4, or 8 weeks. Results: P. gingivalis infection resulted in destruction of the periodontal ligament, reduced bone density, and caused inflammatory cell migration. Radiographic, morphometric, and histological results showed that incadronate had the ability to increase the bone mineral density (quantum level score; cortex 518.9 [placebo 612.8]; sponge 579.8 [placebo 672.0]) and to prevent periodontal ligament destruction (width 0.16 mm [placebo 0.20 mm]; area 0.36 mm 2 [placebo 0.54 mm 2 ]) after 8 weeks' administration. Furthermore, the polymorphonuclear leukocyte (PMN) infiltration in gingival tissue was significantly decreased. Conclusion: These results showed that incadronate inhibits bone resorption and PMN migration in P. gingivalis ‐induced periodontitis. J Periodontol 2003;74:603‐609.