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Treatment of Periodontal Disease in a Patient With Ehlers‐Danlos Syndrome. A Case Report and Literature Review
Author(s) -
Perez Luis A.,
AlShammari Khalaf F.,
Giannobile William V.,
Wang HomLay
Publication year - 2002
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2002.73.5.564
Subject(s) - medicine , etiology , n terminal telopeptide , pyridinoline , ehlers–danlos syndrome , dentistry , disease , dermatology , biochemistry , chemistry , alkaline phosphatase , osteocalcin , enzyme
Background: Ehlers‐Danlos syndrome (EDS) designates a heterogeneous group of connective tissue disorders characterized by skin elasticity, tissue fragility, and chronic joint pain. Dental findings have been reported with some types of EDS. This case report describes the periodontal findings in a patient with a previously undiagnosed EDS type VIII.Methods: Diagnostic aids utilized included microbial testing, histological examination, gingival crevicular fluid (GCF) analysis for the levels of C‐telopeptide pyridinoline cross‐links (ICTP), and genetic counseling. Periodontal treatment consisted of mechanical debridement and adjunctive antibiotic therapy.Results: Genetic counseling and clinical presentation confirmed the diagnosis of EDS type VIII. Periodontal treatment led to marked clinical improvements and GCF levels of the bone resorptive marker ICTP were significantly reduced. The patient and her siblings are currently pursuing appropriate medical care and genetic counseling.Conclusion: Periodontal involvement may lead to the diagnosis of an underlying systemic condition. Identification of suspected etiological factors of periodontal disease may prove critical for the general wellbeing of some patients. J Periodontol 2002;73:564‐570.