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Interactions of Lymphotoxin α (TNF‐β), Angiotensin‐Converting Enzyme (ACE), and Endothelin‐1 (ET‐1) Gene Polymorphisms in Adult Periodontitis
Author(s) -
Hollá Lydie Izakovičová,
Fassmann Antonín,
Vašků Anna,
Znojil Vladimír,
Vaněk Jiří,
Vácha Jiří
Publication year - 2001
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2001.72.1.85
Subject(s) - allele , genotype , periodontitis , taqi , locus (genetics) , gene , genetics , biology , allele frequency , genotype frequency , angiotensin converting enzyme , gene polymorphism , immunology , polymorphism (computer science) , medicine , endocrinology , blood pressure
Background: Adult periodontitis is a complex multifactorial disease whose etiology is not well defined. To investigate whether the genes encoded within the HLA class III region may confer susceptibility to periodontitis, polymorphisms in the ET‐1 and TNF‐β genes were analyzed together with the I/D polymorphism of the ACE gene. Methods: We determined allele and genotype frequencies of the NcoI bi‐allelic polymorphism of the TNF‐β gene, the I/D (insertion/deletion) polymorphism of the ACE gene, and the TaqI polymorphism of the ET‐1 gene in 63 Caucasian patients with adult periodontitis and 95 orally healthy controls. Results: We found a significant difference in a 3 locus combination of genotypes between patients and controls ( P <0.05). In the next analyses, no significant differences were found in allele frequencies of single genes, but we did find a significant difference in the genotype distribution between cases and controls for TNF‐β ( P <0.03). Differences were also observed for 2 locus combinations of ACE and TNF‐β genotypes ( P <0.03), and the ET‐1 and TNF‐β ( P <0.05) genes. Evidence of deviation from Hardy‐Weinberg equilibrium was observed in the periodontitis group for TNF‐β, with an absence of the B 1 B 1 homozygotes in patients. Conclusions: This study is of an exploratory nature. Considering the number of significant results, however, at least a part of the observed associations may obviously be real and our findings suggest that interactions of the TNF‐β, ET‐1, and ACE genes may be involved in susceptibility to adult periodontitis. J Periodontol 2001;72:85‐89 .