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Detection of Platelet‐Activating Factor in Gingival Tissue Surrounding Failed Dental Implants
Author(s) -
Bassi Francesco,
Marchisella Cristiano,
Schierano Gianmario,
Gasser Egon,
Montrucchio Giuseppe,
Valente Guido,
Camussi Giovanni,
Preti Giulio
Publication year - 2001
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2001.72.1.57
Subject(s) - osseointegration , inflammation , implant , medicine , mediator , platelet activating factor , pathogenesis , soft tissue , immunohistochemistry , dentistry , platelet , pathology , thrombogenicity , surgery
Background: Dental implant therapy has entered routine clinical practice. However, the failure rate of implants at 5 years, due to biological factors, is still around 7%. The pathogenesis of implant loss involves a complex network of cells and inflammatory mediators. This study evaluated platelet‐activating factor (PAF), a potent phospholipid mediator of inflammation, in soft tissue surrounding failed dental implants versus healthy implants. Methods: PAF was estimated on extracted lipids by bioassay on washed rabbit platelets; inflammatory cell populations were assessed semiquantitatively after staining, and microvessel density was evaluated after immunohistochemical staining. Results: Biologically active PAF was detected in the lipid extracts of samples excised from gingival tissue of patients with failed implants, but not in samples from patients with osseointegrated implants or from healthy edentulous subjects. The amount of PAF detected in failed implants was significantly higher than in healthy implants, suggesting a local production of this mediator. Conclusions: The presence of PAF was associated with histopathological findings of local inflammation and increased blood vessel density. J Periodontol 2001;72:57‐64.