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Cyclosporine A‐Induced Gingival Hyperplasia Pemphigus Vulgaris: Literature Review and Report of a Case
Author(s) -
OettingerBarak Orit,
Machtei Eli E.,
Peled Micha,
Barak Shlomi,
LNaaj Imad Abu,
Laufer Dov
Publication year - 2000
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2000.71.4.650
Subject(s) - medicine , pemphigus vulgaris , gingival enlargement , oral hygiene , scaling and root planing , dentistry , gingival inflammation , gingival and periodontal pocket , root caries , gingivectomy , hyperplasia , dermatology , periodontitis , gingivitis , chronic periodontitis
Gingival hyperplasia appears in 8% to 85% of patients treated with cyclosporine. Most studies show an association between oral hygiene status and the prevalence and severity of this gingival overgrowth. Thus, besides attempting to substitute this drug with another whenever possible, treatment usually involves maintenance of strict oral hygiene coupled with scaling and root planing and removal of iatrogenic factors. Sometimes a second treatment phase involving periodontal surgery is necessary. Cyclosporine‐induced gingival overgrowth has been mainly described in post‐organ transplant patients. The present case describes, for the first time, a severe form of cyclosporineinduced gingival overgrowth arising in a 15 year‐old male with pemphigus vulgaris. Periodontal treatment included oral hygiene and scaling and root planing under local anesthesia. There was a significant reduction in gingival enlargement, as well as a reduction in plaque levels and inflammation. Cessation of drug administration, combined with continuous periodontal treatment, brought further improvement. This successful conservative treatment of cyclosporine‐induced gingival overgrowth in a pemphigus vulgaris patient suggests that early diagnosis and comprehensive treatment of these lesions may yield good response and reduce the need for periodontal surgery. J Periodontol 2000;71:650‐656.