z-logo
Premium
Enamel Matrix Derivative in the Treatment of Human Intrabony Osseous Defects
Author(s) -
Okuda Kazuhiro,
Momose Manabu,
Miyazaki Akira,
Murata Masashi,
Yokoyama Shigeru,
Yonezawa Yukari,
Wolff Larry F.,
Yoshie Hiromasa
Publication year - 2000
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2000.71.12.1821
Subject(s) - enamel matrix derivative , placebo , medicine , dentistry , placebo group , orthodontics , alternative medicine , pathology , regeneration (biology) , biology , microbiology and biotechnology
Background: There is limited information available from clinical trials regarding the performance of enamel matrix derivative (EMD) in the treatment of periodontal intrabony defects. This randomized, double‐blind, placebo‐controlled, split‐mouth study was designed to compare the clinical and radiographical effects of EMD treatment to that of placebo‐controlled treatment for intrabony defects. Methods: Sixteen patients were included, each of whom had 1 or 2 pairs of intrabony defects located contralaterally in the same arch. Thirty‐six intrabony defects were randomly assigned treatment with flap surgery plus EMD or flap surgery plus placebo. At baseline and at the 12‐month follow‐up evaluation visit, clinical and radiographic measurements were determined. Data were statistically analyzed using the Wilcoxon‐signed rank test (α = 0.05). Results: At the 12‐month visit, bleeding on probing for the EMD group was 0.11 ± 0.32 compared to the placebo group, 0.61 ± 0.50 ( P <0.05). Probing depth reduction was greater in the EMD group (3.00 ± 0.97 mm) compared to the placebo group (2.22 ± 0.81 mm) ( P <0.05). Mean values for clinical attachment gain in the EMD and the placebo groups were 1.72 ± 1.07 mm and 0.83 ± 0.86 mm, respectively ( P <0.05). Vertical relative attachment gain was 38.5 ± 22.6% in the EMD group and 21.4 ± 25.2% in the placebo group ( P <0.05). Radiographic bone density gain was greater in the EMD (20.2 ± 16.6%) compared to the placebo group (−3.94 ± 23.3%) ( P <0.01). Conclusions: Treatment with flap surgery and EMD, compared to flap surgery with placebo, produced a significantly more favorable clinical improvement in intrabony periodontal defects. J Periodontol 2000;71:1821‐1828.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here