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Effects of Cyclosporin A on Alveolar Bone: An Experimental Study in the Rat
Author(s) -
Fu Earl,
Hsieh YaoDung,
Nieh Shin,
Wikesjö Ulf M.E.,
Liu Demeral
Publication year - 1999
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1999.70.2.189
Subject(s) - dental alveolus , alveolar crest , medicine , hyperplasia , mandible (arthropod mouthpart) , alveolar process , bone histomorphometry , dentistry , pathology , biology , trabecular bone , osteoporosis , botany , genus
Background: There have been several investigations on the role of cyclosporin A (CSA) in gingival hyperplasia in both animals and humans. However, less attention has been given to the drug's effect on alveolar bone. This study used light microscopy to histologically and histometrically evaluate the effects of CSA on alveolar bone in the rat. Methods: Sixty, 6‐week‐old Sprague‐Dawley rats were separated into test and control groups. Animals in the test group received CSA in mineral oil (30 mg/kg body weight) daily by gastric feeding over the 6‐week study. Control animals received only mineral oil. Ten animals from each group were sacrificed at weeks 2, 4, and 6. After histologic processing, the labial crest of the alveolar bone in the anterior mandible was evaluated by light microscopy. Results: A distinct pattern of increased osteoclasia and reduced bone formation was observed in the CSA‐exposed animals compared to the controls. Increased osteoclasia was observed in periodontal sites and decreased bone formation was observed in symphyseal sites. Conclusions: The results suggest that CSA has distinct effects on alveolar bone. J Periodontol 1999;70:189‐194.