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Role of Interactions Between Integrins and Extracellular Matrix Components in Healthy Epithelial Tissue and Establishment of a Long Junctional Epithelium During Periodontal Wound Healing: A Review
Author(s) -
Gräber HansGeorg,
Conrads Georg,
Wilharm Jens,
Lampert Friedrich
Publication year - 1999
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1999.70.12.1511
Subject(s) - extracellular matrix , microbiology and biotechnology , integrin , wound healing , regeneration (biology) , cell adhesion molecule , epithelium , matrix (chemical analysis) , cell adhesion , biology , chemistry , cell migration , cell , immunology , biochemistry , genetics , chromatography
Following the surgical treatment of adult periodontitis, the epithelial regeneration of the periodontal attachment is non‐physiological and thus unsatisfactory, if membranes or artificial bone material are not used. Re‐epithelialization is based on the proliferation, migration, and differentiation of basal epithelial cells which are in contact with a wound matrix and whose molecular makeup differs from the extracellular matrix of intact regions. Interactions between basal epithelial cells and the extracellular matrix are mediated by special receptors on the cell surface which are known as integrins and belong to the family of cellular adhesion molecules (CAM). Various studies indicate that integrin‐mediated interaction plays a decisive role in regulating the proliferation, migration, and differentiation of the epithelial cells. This review provides an overview of the in vivo and in vitro expression of integrins by epithelial cells and the interaction between integrins and extracellular matrix (ECM) in the case of a stationary epithelium and during wound healing. The regulation of these cell‐cell and cell‐matrix interactions may represent a method for inhibiting non‐physiological epithelial regeneration on the molecular level. J Periodontol 1999;70:1511‐1522.