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Clinical and Microbiologic Effects of Adjunctive Antibiotics in Treatment of Localized Juvenile Periodontitis. A Controlled Clinical Trial
Author(s) -
Tinoco Eduardo M.B.,
Beldi Maria I.,
Campedelli Flavia,
Lana Marcia,
Loureiro Carlos A.,
Bellini Hamilton T.,
Rams Thomas E.,
Tinoco Neyde M.B.,
Gjermo Per,
Preus Hans R.
Publication year - 1998
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1998.69.12.1355
Subject(s) - medicine , metronidazole , placebo , periodontitis , antibiotics , actinobacillus , amoxicillin , dentistry , adverse effect , clinical trial , population , dental alveolus , randomized controlled trial , chronic periodontitis , gastroenterology , pathology , microbiology and biotechnology , biology , alternative medicine , environmental health
T he aim of this study was to assess the clinical and microbiologic effects of the combination of amoxicillin and metronidazole therapy as an adjunct to mechanical treatment in the management of localized juvenile periodontitis. Twenty‐five localized juvenile periodontitis (LJP) patients from a Brazilian population were randomly allocated into an experimental group receiving mechanical treatment and antibiotics, and a control group receiving mechanical treatment and placebo. Clinical and radiographic assessments, as well as microbiologic sampling for Actinobacillus actinomycetem.comitans , were performed at baseline and one year after the end of the treatment. At the termination of the study A. actinomycetemcomitans could be isolated from the oral cavity of all patients in the control group who harbored the bacterium at baseline and in 4 out of 8 patients in the experimental group. Both treatment modalities resulted in significant benefit on an individual basis. The experimental group, however, displayed better results than did the control group regarding gingival index (GI), probing depth (PD), clinical attachment level (CAL), and radiographic analysis of crestal alveolar bone mass, but not with respect to plaque index (PI). No serious adverse effects of the antibiotic treatment were observed in the present study. J Periodontol 1998;69:1355–1363 .