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Periodontal Regeneration in Naturally Occurring Class II Furcation Defects in Beagle Dogs After Guided Tissue Regeneration With Bioabsorbable Barriers
Author(s) -
Bogle Gary,
Garrett Steven,
Stoller Norman H.,
Swanbom Deryl D.,
Fulfs Jon C.,
Rodgers Peter W.,
Whitman Susan,
Dunn Richard L.,
Southard G. Lee,
Polson Alan M.
Publication year - 1997
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1997.68.6.536
Subject(s) - cementum , furcation defect , beagle , junctional epithelium , buccal administration , periodontal fiber , regeneration (biology) , dentistry , barrier membrane , coronal plane , chemistry , medicine , anatomy , pathology , epithelium , molar , biology , dentin , biochemistry , membrane , microbiology and biotechnology
T he efficacy of a bioabsorbable polylactic acid based barrier was evaluated using naturally occurring buccal Class II furcation defects in beagle dogs. Sixteen furcation sites (8 control and 8 experimental) were treated in 6 adult animals. After full thickness flap reflection, exposed furcations and root surfaces were thoroughly root planed. In experimental sites a customized barrier was formed and fitted to cover the defect. Surgical flaps were replaced slightly coronal to the cemento‐enamel junction. Animals were sacrificed at 6 months and specimens processed for histologic evaluation. Histologic and histometric analyses were done using 6 μm step serial sections in the buccal‐lingual plane, corresponding to the buccal‐lingual extent of the furcation. Results were: mean total defect experimental sites 1.92 mm; control sites 1.47 mm. Mean new cementum formation experimental sites 1.36 mm (71% of initial defect); control sites 0.25 mm (17% of initial defect). Mean new bone formation experimental sites 1.42 mm (74% of initial defect); control sites 0.20 mm (14% of initial defect). Mean junctional epithelium formation experimental sites 0.42 mm (22% of initial defect); control sites 1.21 mm (82% of initial defect). Statistical analysis demonstrated significant differences in all healing parameters favoring experimental (barrier‐treated) sites. In this model, regeneration (new bone, cementum, and periodontal ligament) of 71% of the original defect in experimental sites and only 14% in control sites demonstrated a response that highly favored use of the barrier. J Periodontol 1997;68:536–544 .