Premium
Active and β‐1 Proteinase Inhibitor Complexed Leukocyte Elastase Levels in Crevicular Fluid From Patients With Periodontal Diseases
Author(s) -
Meyer Jean,
Guessous Fadila,
Huynh Christine,
Godeau Gaston,
Hornebeck William,
Giroud JeanPaul,
RochArveiller Monique
Publication year - 1997
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1997.68.3.256
Subject(s) - elastase , proteinase inhibitor , gingival and periodontal pocket , periodontal disease , chemistry , periodontitis , medicine , dentistry , biochemistry , enzyme
H uman leukocyte elastase is present in large amounts in the crevicular fluid of patients with periodontal disease and was considered as a putative biological marker of the evolution of such diseases. The aim of this work was to measure spectrophotometrically amounts of active elastase (AE) and elastase complexed to α 1 proteinase inhibitor (E‐α 1 ‐PI) in gingival crevicular fluid obtained from patients suffering from rapidly progressive periodontitis (RPP group) or adult periodontitis (AP group) with different probing depths (3 to 5 mm and > 6 mm). AE and E‐α 1 ‐PI concentrations were negligible in healthy individuals. AE, but not E‐α 1 ‐PI, concentration appears to vary significantly with the probing depth in patients suffering either from rapidly progressive or adult periodontitis. No correlations were found between levels of AE and E‐α 1 ‐PI in the different groups of patients. AE concentration seems to be a marker of periodontal diseases in relation with probing depth. J Periodontol 1997;68:256–261 .