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Alterations in Phagocyte Function and Periodontal Infection
Author(s) -
Daniel Michael A.,
Van Dyke Thomas E.
Publication year - 1996
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1996.67.10s.1070
Subject(s) - phagocyte , macrophage , periodontitis , immunology , inflammation , phagocytosis , medicine , function (biology) , lesion , pathology , biology , in vitro , dentistry , microbiology and biotechnology , biochemistry
A review of phagocytic cells –polymorphonuclear leukocytes and monocytes–in the inflammatory process is presented. Examples of phagocyte defect‐related pathology serve as a framework for understanding the role of these cells in periodontal infection. The role of alterations in neutrophil function in localized juvenile periodontitis is presented as a model system for understanding periodontal pathology as a result of host‐related functional abnormalities. Two topical alternative hypotheses for periodontal breakdown are presented in which. macrophage control of the chronic lesion is altered by an absence of T cells or the influence of bacterial superantigens. J Periodontol 1996;67:1070–1075 .