Gingival Langerhans' Cells in Type I Diabetes Mellitus | Zendy

Günhan Meral | Zendy; Günhan Omer | Zendy; Celasun Bülent | Zendy; Azal Ömer | Zendy; Bostanci Hamit | Zendy

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Gingival Langerhans' Cells in Type I Diabetes Mellitus

Author(s) -

Günhan Meral,

Günhan Omer,

Celasun Bülent,

Azal Ömer,

Bostanci Hamit

Publication year - 1996

Publication title -

journal of periodontology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.036

H-Index - 156

eISSN - 1943-3670

pISSN - 0022-3492

DOI - 10.1902/jop.1996.67.1.37

Subject(s) - gingivitis , medicine , diabetes mellitus , type 2 diabetes mellitus , immunohistochemistry , pathology , langerhans cell , dentistry , endocrinology , immunology , antigen

Langerhans' cells (LC s ) are intraepithelial immunocompetent cells. Changes in the number of LCs occur in inflammatory and autoimmune diseases. In this study, the number of gingival LCs in patients with type I diabetes mellitus was compared with those of normal individuals using immunohistochemical methods. Gingival biopsies were obtained from 20 type I diabetics and 10 healthy individuals. Anti‐CD1 positive LCs formed an intraepithelial network and showed a marked increase in type I diabetics. This increase was not related to diabetic age. The number of LCs was proportional to the density of subepithelial inflammatory cells. Our findings suggest that LCs may play a role in the development of diabetic gingivitis. J Periodontol 1996;67:37–40 .

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