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Gingival Langerhans' Cells in Type I Diabetes Mellitus
Author(s) -
Günhan Meral,
Günhan Omer,
Celasun Bülent,
Azal Ömer,
Bostanci Hamit
Publication year - 1996
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1996.67.1.37
Subject(s) - gingivitis , medicine , diabetes mellitus , type 2 diabetes mellitus , immunohistochemistry , pathology , langerhans cell , dentistry , endocrinology , immunology , antigen
Langerhans' cells (LC s ) are intraepithelial immunocompetent cells. Changes in the number of LCs occur in inflammatory and autoimmune diseases. In this study, the number of gingival LCs in patients with type I diabetes mellitus was compared with those of normal individuals using immunohistochemical methods. Gingival biopsies were obtained from 20 type I diabetics and 10 healthy individuals. Anti‐CD1 positive LCs formed an intraepithelial network and showed a marked increase in type I diabetics. This increase was not related to diabetic age. The number of LCs was proportional to the density of subepithelial inflammatory cells. Our findings suggest that LCs may play a role in the development of diabetic gingivitis. J Periodontol 1996;67:37–40 .