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Effect of Tetracycline HCl on Periodontally‐Affected Human Root Surfaces
Author(s) -
Trombetti Leonardo,
Scabbia Alessandro,
Zangari Francesca,
Griselli Alessandra,
Wikesjö Ulf M.E.,
Calura Giorgio
Publication year - 1995
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1995.66.8.685
Subject(s) - tetracycline , dentistry , tooth root , chemistry , medicine , antibiotics , biochemistry
S canning electron microscopy was used to evaluate surface characteristics of periodontitis‐exposed instrumented human cementum and dentin surfaces following topical application of tetracycline HCl (TTC). Specimens were randomly assigned to application of sterile saline for 1 minute (control); TTC (10 mg/ml) for 1 minute and 4 minutes, respectively; and TTC (100 mg/ml) for 1 minute and‐4 minutes, respectively. Solutions were applied with a cotton pellet using a burnishing technique. Control specimens exhibited an amorphous irregular surface smear layer. TTC treatment of cementum for 1 minute resulted in a relatively debris‐free, nonhomogeneous surface. The 4‐minute application resulted in a surface exhibiting a densely fibrillar, matlike texture. Dentin specimens conditioned for 1 minute showed a smooth surface with many tubule openings partially occluded by debris. The 4‐minute treatment exposed a 3‐dimensional network of intertubular and peritubular collagen fibrils. No consistent morphologic differences were observed between cementum or dentin specimens treated with TTC at concentrations of 10 and 100 mg/ml, respectively. The results suggest that topical application of TTC produces morphologic alterations of periodontitis‐exposed cementum and dentin that appear related to application interval rather than concentration of the drug. J Periodontol 1995;66:685–691 .