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Response of Regenerative Tissues to Plaque: A Histological Study in Monkeys
Author(s) -
Ling Lijane,
Lai Yulin,
Hwang Hueyhwa,
Chen Henry
Publication year - 1994
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1994.65.8.781
Subject(s) - medicine , regeneration (biology) , pathology , dentistry , wound healing , tissue engineering , anatomy , surgery , biomedical engineering , biology , microbiology and biotechnology
T his study was designed to determine the histologic response of regenerated tissue to plaque, using an adult Taiwan monkey model with chronically‐inflamed, surgically‐created, periodontal defects. Standardized 2‐walled periodontal defects were surgically created at the mesial of the mandibular lateral incisor on one side. Sutures, 3‐0 braided silk, were placed for 8 weeks and tissues positioned so that denuded root surfaces were exposed to plaque, with the subsequent development of the chronically‐inflamed periodontal tissues. At 8 weeks the defects were subjected to guided tissue regeneration procedures using expanded polytetrafluoroethylene membrane and allowed to heal for 6 months. Contralateral clinically healthy sites, without surgical procedures, were used as controls. In both experimental (membrane) and control sites, silk ligatures were placed to allow plaque accumulation for 2 or 10 weeks. Four monkeys were sacrificed at each time point and specimens processed for histologic and histometric study. The results indicated that plaque‐induced inflammation was less at sites treated by guided tissue regenerative procedures when compared to originally clinically‐healthy sites exposed to plaque for the same duration. However, histologically the newly formed osseous tissue was compromised under these conditions. J Periodontol 1994; 65:781–787 .