Identification and Semi‐Quantification of Estrogen and Progesterone Receptors in Peripheral Giant Cell Lesions of the Jaws | Zendy

Whitaker S. Bryan | Zendy; Bouquot Jerry E. | Zendy

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Identification and Semi‐Quantification of Estrogen and Progesterone Receptors in Peripheral Giant Cell Lesions of the Jaws

Author(s) -

Whitaker S. Bryan,

Bouquot Jerry E.

Publication year - 1994

Publication title -

journal of periodontology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.036

H-Index - 156

eISSN - 1943-3670

pISSN - 0022-3492

DOI - 10.1902/jop.1994.65.3.280

Subject(s) - immunoperoxidase , giant cell , estrogen , peripheral blood mononuclear cell , progesterone receptor , population , cell , receptor , pathology , staining , estrogen receptor , biology , multinucleate , medicine , endocrinology , immunology , antibody , monoclonal antibody , biochemistry , genetics , environmental health , cancer , breast cancer , in vitro

C ases of peripheral giant cell lesions of the jaws (PGCL) were evaluated for the detection of estrogen and progesterone receptor proteins (ERS/PRS) utilizing immunoperoxidase staining. Staining for ERS was strongly positive in three cases when examining the mononuclear cell population. Another two cases were weakly positive. In addition, an occasional ER+ multinucleated giant cell could be observed in three of the cases examined. PRS immunoreactivity was essentially negative in all cases. It is well known that the PGCL has a marked female predilection. This, coupled with the present findings, gives further evidence that some PGCL may be at least partially under hormonal influence. J Periodontol 1994;65:280–283 .

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