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Identification and Semi‐Quantification of Estrogen and Progesterone Receptors in Peripheral Giant Cell Lesions of the Jaws
Author(s) -
Whitaker S. Bryan,
Bouquot Jerry E.
Publication year - 1994
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1994.65.3.280
Subject(s) - immunoperoxidase , giant cell , estrogen , peripheral blood mononuclear cell , progesterone receptor , population , cell , receptor , pathology , staining , estrogen receptor , biology , multinucleate , medicine , endocrinology , immunology , antibody , monoclonal antibody , biochemistry , genetics , environmental health , cancer , breast cancer , in vitro
C ases of peripheral giant cell lesions of the jaws (PGCL) were evaluated for the detection of estrogen and progesterone receptor proteins (ERS/PRS) utilizing immunoperoxidase staining. Staining for ERS was strongly positive in three cases when examining the mononuclear cell population. Another two cases were weakly positive. In addition, an occasional ER+ multinucleated giant cell could be observed in three of the cases examined. PRS immunoreactivity was essentially negative in all cases. It is well known that the PGCL has a marked female predilection. This, coupled with the present findings, gives further evidence that some PGCL may be at least partially under hormonal influence. J Periodontol 1994;65:280–283 .