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Self‐Reported Periodontal Disease in a Virginia Twin Population
Author(s) -
Corey Linda A.,
Nance Walter E.,
Hofstede Patricia,
Schenkein Harvey A.
Publication year - 1993
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1993.64.12.1205
Subject(s) - concordance , proband , medicine , etiology , dizygotic twins , periodontal disease , dizygotic twin , twin study , population , demography , epidemiology , disease , dentistry , heritability , obstetrics , biology , genetics , environmental health , sociology , mutation , gene
T o investigate the contribution of genetic factors in the etiology of periodontal disease, questionnaire data were collected on 4,908 twin pairs included in the populationbased Virginia Twin Registry. A history of periodontal disease was reported in 420 individuals who were members of 116 monozygotic (MZ) and 233 dizygotic (DZ) twin pairs. The mean age at diagnosis in this sample was 31.4±0.7 years and was significantly earlier in females than males (30.1 vs. 33.0 years, P <0.025). Proband‐wise concordance rates were 0.38 for MZ and 0.16 for DZ twins. There were no differences in concordance rate between same and opposite‐sexed dizygotic twins. These findings provide evidence that genetic factors make an important contribution to risk for adult‐onset periodontal disease. J Periodontol 1993;64:1205–1208 .