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Marginal Periodontitis and Cytokines: A Review of the Literature
Author(s) -
Kjeldsen Mette,
Holmstrup Palle,
Bendtzen Klaus
Publication year - 1993
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1993.64.11.1013
Subject(s) - periodontitis , cytokine , immunology , medicine , proinflammatory cytokine , inflammation , dentistry
R ecent research on the immunopathogenesis of marginal periodontitis has focused on cytokines, because these mediators govern biologicial activities in inflammatory tissue destruction. Several studies have been carried out to elucidate the involvement of cytokines in periodontitis, including cytokine measurements in samples from gingival tissue, gingival crevicular fluid, and in supernatants of stimulated in vitro grown cells from gingival tissue and peripheral blood. The results, summarized in this review, suggest that cytokines are involved in the progress of periodontitis. Furthermore, cytokines may be valuable as markers of tissue breakdown. At the present stage, however, there are difficulties in detecting and quantifying cytokines by immunochemical methods and, in particular, by bioassays. Increased knowledge of the cytokine network may open new pathways of periodontitis treatment by controlling processes involved in tissue breakdown. J Periodontol 1993;64:1013–1022.