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Effect of Exogenously Applied Prostaglandin E 2 on Alveolar Bone Loss—Histometric Analysis
Author(s) -
Miyauchi Mutsumi,
Ijuhin Naokuni,
Nikai Hiromasa,
Takata Takashi,
Ito Hiroshi,
Ogawa Ikuko
Publication year - 1992
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1992.63.5.405
Subject(s) - prostaglandin e2 , dental alveolus , bone resorption , prostaglandin e , resorption , osteoclast , chemistry , gingival sulcus , prostaglandin , endocrinology , medicine , dentistry , receptor
T he effect of prostaglandin E 2 (PGE 2 ) on alveolar bone resorption was examined in 8‐week old Wistar rats by histometric analysis. One mg/ml PGE 2 topically applied to gingival sulcus induced a marked increase in osteoclasts. The number of osteoclasts increased progressively and reached a maximum at 12 hours. Ultrastructurally, these osteoclasts were in active form with well developed ruffled borders and clear zones. The changes in numbers of osteoclasts after application of various concentrations of PGE 2 were dose‐dependent (0.001 to 1.0 mg/ml), but higher concentrations of PGE 2 (2 mg/ ml) were less effective. In addition, the number of osteoclasts in groups treated with both PGE 2 and endotoxin was higher than those that received PGE 2 only. These results indicate that bone resorption caused by PGE 2 depends on activation and increase of osteoclasts, and suggests that endogenous PGE 2 production by host cells stimulated by plaque‐associated bacterial endotoxin may be an important pathogenetic factor in periodontal disease. J Periodontol 1992; 63:405–411 .