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Treponema denticola and Porphyromonas gingivalis as Prognostic Markers Following Periodontal Treatment
Author(s) -
Simonson Lloyd G.,
Robinson Peter J.,
Pranger Rory J.,
Cohen Mark E.,
Morton Harold E.
Publication year - 1992
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1992.63.4.270
Subject(s) - treponema denticola , porphyromonas gingivalis , periodontitis , medicine , periodontal disease , chronic periodontitis , antigen , immunoassay , microbiology and biotechnology , dentistry , antibody , immunology , biology
S ubgingival plaque samples were collected from individuals with advanced periodontitis before and 3 to 11 weeks after scaling and root planing periodontal treatment. The plaque levels of Treponema denticola and Porphyromonas gingivalis antigens were measured before and after treatment by a quantitative immunoassay procedure using monoclonal antibodies specific for these oral bacteria. A decrease in mean levels of T. denticola ( P <.05) and P. gingivalis antigens ( P <. 09) were observed following periodontal therapy. Improved health, as measured by a decrease in probing depth, was associated with a decrease in T. denticola antigen ( P <.05). These results suggest that the T. denticola levels of successfully treated sites decreased, while non‐responding sites had levels of this microbial marker which were equal to or greater than the pre‐treatment levels. These results provide additional evidence that T. denticola is associated with human adult severe periodontal disease, and can serve as a prognostic marker for disease recurrence. J Periodontol 1992;63:270–273.