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Principles and Pitfalls of Clinical Trials Design
Author(s) -
Jeffcoat M.K.
Publication year - 1992
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1992.63.12s.1045
Subject(s) - generalizability theory , clinical trial , sample size determination , gingivitis , clinical study design , selection (genetic algorithm) , protocol (science) , medicine , periodontitis , research design , medical physics , adaptive design , computer science , dentistry , alternative medicine , artificial intelligence , pathology , statistics , mathematics
Periodontitis and gingivitis trials can involve many complex experimental designs. The selection of a specific design and the details of the protocol can influence the magnitude of any effect observed, the generalizability of the results, and the clinical significance of the findings. The purpose of this paper is to review selected aspects of clinical trials including the overall clinical experimental design, controls, outcomes, sample size, and patient selection. Particular emphasis will be placed on Periodontitis trials. J Periodontol 1992; 63:1045–1051 .