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Lipid Composition and Biosynthesis in the Gingiva of the Domestic Cat
Author(s) -
Rabinowitz Joseph L.,
Sheridan Olivia,
Craig Ronald G.,
Feldman Roy,
Grossman Edward R,
Harvey Colin E.,
Haskins Mark E.
Publication year - 1991
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1991.62.8.495
Subject(s) - lipid metabolism , composition (language) , chemistry , gingivitis , phospholipid , cats , metabolism , periodontal disease , phospholipase a2 , periodontitis , biochemistry , medicine , enzyme , dentistry , membrane , philosophy , linguistics
P eriodontal disease in the domestic cat may assume debilitating and serious consequences; however, little is known of the biochemical composition or metabolism of feline gingiva in health or disease. In this report the chemical composition and metabolism of gingival lipids from inflamed and non‐inflamed sites is presented and compared to other species with naturally occurring periodontitis. The neutral and phospholipid composition of feline gingiva was found to be distinct from that of porcine and human. As a measure of de novo lipid synthesis, the total incorporation of 14 C‐acetate into fractionated lipid components was determined and revealed an approximate 2 to 3 fold decrease in inflamed versus non‐inflamed gingiva. The decrease in 14 C‐acetate incorporation appeared to result from a 2‐fold increase in free acetate pools in inflamed compared to noninflamed gingival samples, since total lipase and phospholipase activity were comparable in inflamed and non‐inflamed gingiva and total lipid composition was not changed between inflamed and non‐inflamed sites. These data are similar to those reported for periodontally involved human gingival tissue and suggest a common effect of periodontal inflammation on lipid metabolism in both species. J Periodontol 1991; 62:495–498 .