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Periodontal Findings in Adult Twins
Author(s) -
Michalowicz Bryan S.,
Aeppli Dorothee,
Virag John G.,
Klump David G.,
Hinrichs E.,
Segal Nancy L.,
Bouchard Thomas J.,
Pihlstrom Bruce L.
Publication year - 1991
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1991.62.5.293
Subject(s) - heritability , gingivitis , periodontitis , biology , twin study , population , clinical attachment loss , family aggregation , intraclass correlation , genetic correlation , disease , medicine , genetics , dentistry , genetic variation , gene , clinical psychology , environmental health , psychometrics
G ingivitis and periodontitis are among the most common diseases known to man. Although bacterial plaque is generally accepted as the primary etiologic agent, little information is available concerning the influence that host genetic factors have on these diseases. The purpose of the present study was to examine the relative contribution of environmental and host genetic factors to clinical measures of periodontal disease through the study of both reared‐together twins and monozygous twins reared apart. Probing depth, clinical attachment loss, gingivitis, and plaque were assessed from the Ramfjord teeth in 110 pairs of adult twins (mean age 40.3 years), including 63 monozygous and 33 dizygous twin pairs reared together and 14 monozygous twin pairs reared apart. Bootstrap sampling was used to estimate and provide confidence limits of between‐pair and within‐pair variances, intraclass correlations and heritability. Based on ratios of within‐pair variances or heritability estimates, a significant (P<0.05) genetic component was identified for gingivitis, probing depth, attachment loss and plaque. Heritability estimates indicated that between 38% to 82% of the population variance for these periodontal measures of disease may be attributed to genetic factors. While there is general agreement that bacteria are important in the pathogenesis of the periodontal diseases, future etiologic studies should consider the role of host genetic influences. J Periodontol 1991; 62:293–299.