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Neutrophil Surface Protein Markers as Indicators of Defective Chemotaxis in LJP
Author(s) -
Van Dyke T. E.,
Warbington M.,
Gardner M.,
Offenbacher S.
Publication year - 1990
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1990.61.3.180
Subject(s) - chemotaxis , flow cytometry , immunology , aggressive periodontitis , periodontitis , receptor , neutrophile , biology , granulocyte , inflammation , medicine , biochemistry
A bnormalities of neutrophil function have been highly correlated with severe, early onset periodontal diseases. Nonetheless, the identification of these patients and diagnosis of specific disease states, such as LJP or prepubertal periodontitis, are difficult and costly. In this report, the identification and quantification of neutrophil cell surface markers specific to LJP patients with neutrophil Chemotaxis defects are described. GP110 and FMLP receptors were quantified by flow cytometry on neutrophils from LJP patients with neutrophil Chemotaxis defects, LJP patients without Chemotaxis defects, other patients with primary neutrophil Chemotaxis defects, and controls. Results suggest that reduction of GP110 and FMLP receptor on neutrophils is specific for LJP patients who exhibit neutrophil Chemotaxis abnormalities. J Periodontol 1990;61:180–184.