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Defective Neutrophil Chemotaxis in Down's Syndrome Patients and Its Relationship to Periodontal Destruction
Author(s) -
Izumi Y.,
Sugiyama S.,
Shinozuka O.,
Yamazaki T.,
Ohyama T.,
Ishikawa I.
Publication year - 1989
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1989.60.5.238
Subject(s) - chemotaxis , medicine , immunology , neutrophile , inflammation , receptor
T he degree of defective neutrophil Chemotaxis in patients with Down's syndrome (DS) and its relationship to the severity of periodontal disease were studied. Fourteen patients with DS and 14 healthy controls were examined. Oral hygiene, gingival inflammation, and pocket depths were measured in clinical surveys. Bone loss was evaluated on the oral radiographs. Neutrophil Chemotaxis was measured by the agarose plate method and the Boyden chamber method. The chemotactic index of the agarose plate method and the mean numbers of migrated cells of the Boyden chamber method were correlated with statistical significance ( r s = 0.066, P < 0.01). DS patients showed significantly lower Chemotaxis than healthy volunteers with both methods. No difference was shown between the two groups in the random migration of the neutrophils. From the oral radiographie analysis, the DS patients exhibited various prevalence of bone loss which was inversely proportional to the chemotactic index and a significant correlation between them was shown ( r s = ‐0.612 P < 0.05). A significant correlation was also found between the age of the patient and the prevalence of bone loss ( r s = 0.591 P < 0.05). These results indicate that defective neutrophil Chemotaxis influences the progression of periodontal disease in DS patients.