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Different Cross‐Linked Types of Collagen Implanted in Rat Palatal Gingiva
Author(s) -
Minabe M.,
Kodama T.,
Kogou T.,
Tamura T.,
Hori T.,
Watanabe Y.,
Miyata T.
Publication year - 1989
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1989.60.1.35
Subject(s) - connective tissue , tendon , wound healing , biocompatibility , junctional epithelium , type i collagen , collagen fiber , dentistry , epithelium , chemistry , anatomy , pathology , medicine , surgery , organic chemistry
C ollagen membrane preparations were manufactured with the aim of enhancing wound healing following periodontal surgery. After crosslinking by various processing methods (with ultraviolet and hexamethylenediisocyanate) and to various extents, two types of collagen (atelocollagen and tendon collagen) were implanted into a dissection site within palatal gingival tissue. The time course of healing responses was investigated histologically. Collagen implantation was found to accelerate fibrous connective tissue attachment to the root surface and inhibit apical migration of the junctional epithelium. Cross‐linked atelocollagen was superior in biocompatibility to the other collagen membranes studied.