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Rapidly Progressive Acute Periodontal Infection in a Patient with Acute Leukemia
Author(s) -
Stansbury Dianna M.,
Peterson Douglas E.,
Suzuki Jon B.
Publication year - 1988
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1988.59.8.544
Subject(s) - medicine , lesion , aplasia , gingivitis , acute leukemia , periodontitis , leukemia , biopsy , bone marrow , pathology , herpes simplex virus , feline leukemia virus , immunology , virus , dentistry
T he clinical course of an adult patient with acute lymphocytic leukemia and localized, rapidly progressive periodontal disease in a setting of marrow regeneration is described. Initial presentation of this condition was consistent with herpes simplex virus infection involving the gingiva; however, more extensive evaluation including radiographs, cultures and biopsy revealed necrotic tissue, nonspecific bacterial growth and acute gingival inflammation, with no evidence of viral infection. While most acute oral infections in chemotherapy patients occur during the development of marrow aplasia, this lesion initially developed late during the marrow recovery phase. The characteristics of this lesion are compared with those occurring in noncancer patients with rapidly progressive Periodontitis and who have genetically governed neutrophil and/or lymphocyte defects.