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A Comparison of the Reactivity of Eubacterium Species with Localized and Serum Immunoglobulins from Rapidly Progressive and Adult Periodontitis Patients
Author(s) -
Martin Stephen A.,
Falkler William A.,
Vincent Jack W.,
Mackler Bruce F.,
Suzuki Jon B.
Publication year - 1988
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1988.59.1.32
Subject(s) - periodontitis , titer , antibody , antibody titer , immunology , medicine , pathology , microbiology and biotechnology , biology
I mmunoglobulins in sera and in supernatant fluids of explant cultures of diseased gingival tissues from 20 rapidly progressive and 20 adult Periodontitis sites were tested by an ELISA assay for reactivity with typed strains of Eubacterium alactolyticum , E . brachy , E . limosum and E . nodatum . Immunoglobulins present in tissue culture fluids from both rapidly progressive and adult Periodontitis samples reactive with E . brachy and E . nodatum were significantly greater ( P < 0.05) than those reactive with E . alactolyticum or E . limosum . The titers to E. brachy in tissue culture fluids from adult Periodontitis were significantly greater ( P < 0.05) than those from rapidly progressive Periodontitis; there was no difference in titers to the other three species. The only significant difference in serum titers was that sera from patients with rapidly progressive Periodontitis had significantly greater reactivity to E . alactolyticum than did sera from adult Periodontitis patients. These data indicate that Immunoglobulins in the sera of rapidly progressive and adult Periodontitis patients do not necessarily reflect the reactivity of localized immunoglobulins present in the diseased gingival tissue expiant culture fluids from these patients.