Premium
Human Leukocyte Antigen (HLA) DR 4
Author(s) -
Katz Joseph,
Goultschin Josef,
Benoliel Rafael,
Brautban Chaim
Publication year - 1987
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1987.58.9.607
Subject(s) - human leukocyte antigen , rheumatoid arthritis , immunology , periodontitis , medicine , antigen , periodontal disease , immune system , population , environmental health
The relationship between human leukocyte antigens (HLA) determinants and periodontitis has been examined by several authors without showing any particular pattern. However, no study has investigated the HLA‐D determinants, which are generally associated with immune disorders, and rapidly progressive periodontitis (RPP). The HLA profile of 10 RPP patients was compared with that of a healthy control population ( n = 120). Although no significant difference was found for HLA‐A, HLA‐B, and HLA‐C, HLA‐DR 4 of the HLA‐D group was found in 80% of patients but only in 38.3% of controls. A high frequency of HLA‐DR 4 has been reported in rheumatoid arthritis (RA) patients. This finding may be significant in light of previous reports highlighting similarities between RA and periodontal disease.