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Depressed Leukotriene B 4 Chemotactic Response of Neutrophils from Localized Juvenile Periodontitis Patients
Author(s) -
Offenbacher Steven,
Scott Steven S.,
Odle Bonnie M.,
WilsonBurrows Carolyn,
Van Dyke Thomas E.
Publication year - 1987
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1987.58.9.602
Subject(s) - chemotaxis , leukotriene b4 , juvenile , periodontitis , aggressive periodontitis , neutrophile , leukotriene , medicine , immunology , inflammatory response , inflammation , biology , receptor , asthma , genetics
Previous studies have demonstrated that certain local juvenile periodontitis (LJP) patients possess neutrophils with an intrinsic chemotactic defect to the peptide chemoattractants f‐met‐leu‐phe (FMLP) and C5a. In this investigation, the in vitro response of neutrophils to the chemotactic agent leukotriene B 4 (LTB 4 ) was examined. Those LJP patients who possessed defective chemotactic responses to FMLP and endotoxin activated serum (EAS) also had impaired Chemotaxis to LTB 4 . Exogenous LTB 4 failed to augment the impaired response to FMLP. Evidence for a global membrane defect in LJP neutrophils resulting in hyporesponsiveness to chemically diverse chemotactic agents is presented.